Lyophilization Process Development Workshop
This 2 ½ day workshop combines lectures with work in the laboratory to demonstrate design of lyophilization cycles and the dependence of the process on the thermal behavior of the formulation. Efficient lyophilization cycles are desired to reduce the cost of manufacturing and to aid in production planning. The challenge is that much of time used in new product development is spent on drug design, analytical method development, and stability studies. This leaves little time for the development of an efficient lyophilization cycle and can lead to freeze drying methods that vary widely between companies. Attendees work in groups to examine formulations containing pharmaceutical excipients. Each group builds data sets for their formulation using differential scanning calorimetry (DSC), freeze dry microscopy, and micro freeze dryers. Thermal analysis equipment is used to identify the critical product temperature for the formulation, such as the eutectic temperature or a collapse temperature. The micro freeze dryers are equipped with freeze drying technology developed by Millrock Technology. The equipment includes heat flow sensors and controlled nucleation for use during the workshop. There is ample opportunity to discuss, analyze, and share the data between the groups and opportunity to discuss challenges with experts in lyophilization research and development.
Previous participants hailed from the pharmaceutical, food sciences, diagnostics, and tissue preservation industries. The case studies and lectures are based on freeze drying of pharmaceuticals, but the material, equipment, and interactive discussions apply to all industries.
This date is designed to coincide with the International Society of Lyophilization—Freeze Drying (ISLFD) conference in Chicago. It is our hope that attendees can maximize their trip by attending the technical presentations, poster presentations, and networking sessions at the conference.
REGISTRATION FEE INCLUDES:
- Hands-on experience with Millrock MicroFD Development freeze dryer
- Hands-on experience with McCrone Freeze Dry Microscope System
- Hands-on experience with Computrac Vapor Pro XL Karl Fischer Alternative
- Hands-on experience with Mettler DSC
- Hotel accommodations, including breakfast, at the DoubleTree by Hilton Chicago-Oak Brook
- Lunches and dinner on Monday night
- Transportation to and from our facility/hotel
You may enjoy our On-Demand webinars on lyophilIzation: