Direct Analysis in Real Time Mass Spectrometry (DART®-MS), a time-of-flight molecular ion mass spectrometer, can analyze a wide variety of samples—in situ and without sample preparation—by mass spectrometry. DART-MS utilizes a helium plasma stream set to a desired temperature and polarity to vaporize and ionize molecules from a liquid or solid sample. A DART-MS spectrum shows the molecular ions of the sample components, unlike the fragmentation pattern typically seen in electron ionization (EI) modes of most mass spectrometers. DART-MS spectra are used to identify organic compounds in a sample, typically as a screening method for other mass spectrometry techniques.
DART-MS overcomes many issues associated with sample preparation because of its ability to analyze large samples in air and without contamination. DART-MS can analyze a wide variety of liquid and solid samples, including powders, pharmaceutical tablets and surfaces of wipes and other substrates. Common DART-MS applications are unknown material identification, trace contaminants, and residue analysis.
The instrument is composed of two components, the SVP-DART ion source (IonSense, Inc., Saugus, MA, USA) and a time-of-flight mass spectrometer, the JMS-T100LC AccuTOFTM (JEOL, Peabody, MA, USA). Both JEOL and IonSense software are used for instrument operation, and third-party software is utilized along with the NIST Spectral Database for mass spectral analysis.
As we celebrate our 60th anniversary, we thank you for entrusting us with nearly 60,000 of your materials analysis projects.
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