Linkam FDVS

SIMULATE INDUSTRIAL PROCESSES

Along with vacuum, temperature (-100°C to 125°C) can be accurately controlled and programmed to simulate industrial procedures and determine ideal drying parameters. The process is quick and utilises small volumes of sample, ultimately reducing sample wastage and saving on costs.

ACCURATE TEMPERATURE AND VACUUM SENSING

The system is fitted with two vacuum sensor types ensuring accurate detection of the transition between primary and secondary drying. The dipping thermocouple accurately measures the temperature reading within the lyophilisation vials and a platinum sensor in the shelf provides accurate stage temperature detection.

REAL TIME IMAGING

With the 10x Darkfield lens and control of the X,Y and Z axis, the system is optimised for capturing the freeze drying process. The arrangement of the optical set-up allows for structural changes to be seen as they occur in the lyophilisation vials.

MULTIPLE VIAL COMPATIBILITY

Compatible with most standard freeze drying vials (2R (up to seven vials), 4R, 8R, 10R, 15R and 20R).

MOISTURE CAPTURE

The built in cold trap captures excess moisture and removes it from the vacuum system.

Technical Specifications are Subject to Change

Temperature Range:  -100°C to 50°C

Heating Rate:  0.01°C to 30°C

Block Type:  Silver Cooling Block

Pressure Range:  40mTorr to Standard Pressure

Compatible Vials:  2R (up to seven vials), 4R, 8R, 10R, 15R and 20R

Pressure Sensors:  Pirani and Capacitive

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Dr Zixin Huang, University of Erlangen, Research Group of Dr H. Giesler:

“The idea of designing the FDVS system is not just to make a mini-scale freeze dryer but also to create a versatile platform, with which one is able to quantitatively evaluate the freeze-drying process under controlled condition within a single vial. The purpose of this system is to facilitate the freeze-drying cycle design and process transfer.

Process parameters such as sublimation rate and resistance to vapour flow can be determined during the drying process. By this means, the freeze-drying cycle under given condition could be quantitatively assessed. With the optical unit, which is equipped with a darkfield lens, one is also able to observe the freezing and drying process, which would be helpful for better understanding the drying behaviour”.