A High-Resolution Look at Glass Delamination Using Transmission Electron Microscopy (American Laboratory)

A High-Resolution Look at Glass Delamination Using Transmission Electron Microscopy
Elaine F. Schumacher
American Laboratory – April 1, 2013

Formation of glass delamination flakes and secondary products through reaction of injectable pharmaceutical solutions with glass vial packaging leads to product contamination and costly recalls. Characterization of vials and products by a variety of techniques elucidates delamination mechanisms and drives development of packaging materials and processes to reduce the risk of delamination. Understanding of glass delamination is enhanced by the use of transmission electron microscopy (TEM), a high-resolution characterization technique that provides structural, elemental, and crystallographic information at the micro-level.

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