Thermal microscopy (TM) is a valuable tool for the understanding of solid-state form in pharmaceutical development. It can be used for form discovery, for form understanding, for determination of the thermodynamically stable polymorph, and for the determination of lyophilization cake collapse temperature. This course emphasizes the practical uses and applications of TM through the presentation of theory, through case studies, but mostly through the direct use of the technique by the student. The course covers the study of polymorphs, solvates, hydrates, liquid crystals, racemic mixtures, and freeze-dry mixtures. The course is taught by Dr. Robert Carlton, who has more than 25 years of experience in pharmaceutical development and is the author of the 2011 Springer textbook Pharmaceutical Microscopy.
Upon satisfactory completion of this course students have:
This course is intended for pharmaceutical scientists who need a good understanding of thermal microscopy and how it is used to help develop proficiency with solid-state drug properties.
Job titles for students taking this course include instrument operators, lab facility managers, materials scientists, technicians, and advanced undergraduates or graduate students.
All necessary materials and instruments will be provided to the student for classroom use.
Students are expected to successfully complete a variety of tasks in the form of hands-on exercises, laboratory exercises, identifications of unknowns, and quizzes. Students are notified at the end of the course whether or not they have successfully completed the requirements of the course based on:
Upon successfully meeting these requirements, a student is awarded a certificate of completion and CEU credits, if available. Those who have not successfully passed the course requirements do not receive a certificate or CEU credits.