The difference between two phases of the same composition can mean the difference between useful or toxic. This is true of materials including pharmaceuticals and food additives. X-ray diffraction (XRD), in use for more than 100 years, can quickly distinguish between crystalline phases of a wide variety of materials such as active pharmaceutical ingredients, paints and pigments, and corrosion.
Good analysis starts with good sample prep. Each different type of matrix presents its own unique challenges to particle isolation. This webinar will introduce attendees to some of the specific challenges of different matrices, and provide guidance and information for particle isolation, best practices for submitting samples, and discuss instances when the matrix should also be included with the sample.
Ever experience problems with adhesion, printing, passivation, delamination, or other issues with surfaces of products? Any time surfaces interact with other surfaces, or the environment, much of the interesting chemistry occurs in the outermost few atomic layers. Such thin layers can be difficult to analyze with common methods such as SEM, EDS, XRF, IR, chromatography, and bulk analysis techniques, but XPS is an electron spectroscopy method well-suited for these types of problems. The case studies presented show how XPS may be used to investigate surface performance issues of industrial processes. 30 minutes.
An understanding of lighting sources and even modest particle manipulation skills can unlock a new understanding of particle identification. Macroscopic observation of “dark” particles may reveal that they have distinctive shape/color or that the particles are heterogeneous rather than homogeneous, etc. Various light sources and their use will be discussed as well as a few “teases” about particle preparations that create homogeneous samples for instrumental analysis from heterogeneous samples. This brief webinar, presented by Bill Chapin, focuses on the powerful use of stereomicroscopy – the beginning point of nearly all of the analyses performed at McCrone Associates. 59 minutes.
Meeting 21 CFR Part 11 software requirements has never been easier with the PAX-it! Extended Security Module. For more than 20 years, the intuitive PAX–it framework has provided image analysis and management tools which allow you to measure and annotate images, create custom reports, and store digital assets in a secure database. Now they have added additional layers of protection to ensure you meet the high security standards set by the FDA. 21 minutes.
In our world of analytical microscopy, we are often asked to locate some known, or even unknown, materials in a bulk matrix. Multiple purposes for this type of request can include identification of contaminants, particle size distribution of specific materials, relative quantities of various materials, identification of compound(s), relative special relationship of materials, etc. This type of investigative analysis is often referred to as searching for the “needle in the haystack” (why was a needle chosen and not something else?).
I prefer to use the "Where's Waldo?" dilemma analogy. In analytical microscopy, we can conduct searches utilizing a variety of instrumentation and methodologies to produce “maps,” thus revealing the specific material(s) of interest. Examples will be featured in the content of this webinar. 37 minutes.
Join Gregory Sacha, Ph.D. of Baxter BioPharma Solutions for an introduction to lyophilization and the anatomy of a lyophilizer. Presented in front of a laboratory-scale lyophilizer, Dr. Sacha demonstrates placement of a thermocouple, manual loading, and discusses process parameters and equipment design that affect lyophilization cycles. Hooke College of Applied Sciences offers a freeze drying course. 20 minutes.
Hooke College of Applied Sciences offers a unique 3+1 learning program in cooperation with local colleges and universities that allows students to spend an entire year learning from the leading experts in the field of materials sciences, resulting in the acquisition of valuable skills that are highly sought after by employers. 18 minutes.
Benchtop scanning electron microscopes (SEMs) have come a long way since they were introduced. With capabilities including magnifications up to 60,000X, multiple accelerating voltages, and both SE and BSE detectors, these smaller versions of full-size SEMs are increasingly finding their way into industrial and educational laboratories. Watch this exciting webinar and learn about the new JEOL NeoScope JCM-6000PLUS offered by McCrone Microscopes & Accessories. 20 minutes.
We’ll demonstrate just how good the new detector technology has become. 22 minutes.
Learn some of the current technology utilized for evaluating/characterizing beverage and food packaging defects. 55 minutes.
An integrated approach to particle identification aids in identifying and sourcing foreign particulates in pharmaceutical products. 58 minutes.
Are you a knob tweaker or a knowledgeable operator? During this webinar, you will learn how to make informed decisions when setting up and adjusting your SEM, resulting in obtaining better information, in less time, from your sample. 71 minutes.
For many materials, the results from the NeoScope benchtop SEM are equivalent to research grade systems that cost several hundred thousand dollars more and require their own room. 37 minutes.
Investigational analysis at the particle level can often answer questions raised when your testing results are not what you expected. 37 minutes.
Learn how transmission electron microscopy with energy dispersive X-ray spectrometry (TEM/EDS) can provide improved identification of glass delamination flakes and secondary products formed in injectable drug products. 37 minutes.
At the end of the session, the attendee will be able to develop a well-defined process for taking an empirical approach to designing formulations and the lyophilization cycles used to dry them. By understanding and applying these principles, companies have a much greater chance of getting products approved by the regulatory agencies than companies that employ a "trial and error" approach to formulation and lyophilization cycle design. 80 minutes.
Using a case study example, you will be introduced to different techniques for obtaining infrared spectra, and how to approach evaluation and interpretation of infrared spectra. 24 minutes.
An Introduction to Optical Measuring Systems
A simple introduction to optical measurement. 37 minutes.
Utilizing FDM as Part of a Complete Thermal Characterization Study
for Optimized Lyophilization Cycle Development
Optimizing a lyophilization cycle begins with conducting a thermal characterization study, including freeze-dry microscopy. Identifying the glass transition temperature (Tg’), the eutectic melting temperature (Te), and the collapse temperature allows the development scientist to thoroughly understand how to design the cycle specifically for the product, resulting in the development of a more robust cycle capable of being run in the shortest amount of time. 39 minutes.